July 21st, 2010 Eosinophilic esophagitis linked to chromosome 5 and TSLP gene
A genome-wide association study has led to the discovery of the first major gene site responsible for the severe food allergy eosinophilic esophagitis (EoE) , a disorder that features the accumulation of eosinophils in the esophagus. The investigators found that EoE, which has been increasing over the past 20 years, is linked to a region of chromosome 5 that includes the TSLP gene, which encodes a hematopoietic cytokine called t hymic s tromal l ympho p oietin (TSLP). They also discovered that the TSLP gene exhibits increased activity in esophageal biopsies from children with EoE.
